ea0092op-04-01 | Oral Session 4: Young Investigators / Clinical and Translational | ETA2023
Zinck Jensen Christian
, Lynggaard Isaksen Jonas
, Ahlberg Gustav
, Salling Olesen Morten
, Nygaard Birte
, Ellervik Christina
, Kim Kanters Jorgen
Objectives: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. We investigated, as previously hypothesized, if single nucleotide polymorphisms (SNPs) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the Deiodinase 2 gene (DIO2), or rs17606253 in the Monocarboxylate Transporter 10 gene (MCT10) were associated with outcomes indicative of local tissue hypothyroidism in LT4-tre...